Z-Leu-val-OH

Base Information

• Chemical Name: Z-Leu-val-OH
• CAS No.: 7801-70-9
• Molecular Formula: C19H28N2O5
• Molecular Weight: 364.442
• European Community (EC) Number: 232-257-1
• Nikkaji Number: J268.702J
• Mol file: 7801-70-9.mol

Synonyms:Z-LEU-VAL-OH;7801-70-9;N-cbz-l-leucyl-l-valine;SCHEMBL7355802;MUJSLBXYEJRINU-HOTGVXAUSA-N;NS00046928;(S)-2-((S)-2-(benzyloxycarbonylamino)-4-methylpentanamido)-3-methylbutanoic acid

Chemical Property of Z-Leu-val-OH

Chemical Property:

• Vapor Pressure: 8.99E-15mmHg at 25°C
• Boiling Point: 590.1°Cat760mmHg
• Flash Point: 310.7°C
• PSA: 104.73000
• Density: 1.145g/cm³
• LogP: 3.33470
• Storage Temp.: Store at 0°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 364.19982200
• Heavy Atom Count: 26
• Complexity: 473

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C(C)C)C(=O)O)NC(=O)OCC1=CC=CC=C1
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)OCC1=CC=CC=C1

Technology Process of Z-Leu-val-OH

There total 7 articles about Z-Leu-val-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Leu-OH (2018-66-8) → Z-Leu-Val (7801-70-9)

Guidance literature:

With tetrahydrofuran; chloroformic acid ethyl ester; triethylamine; anschliessend Behandeln mit L-Valin und wss. NaOH;

DOI:10.1021/ja01599a032

Reference yield:

Z-Leu-Val-OMe (4840-30-6) → Z-Leu-Val (7801-70-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/hlca.19680510102

Reference yield:

Z-Leu-OH (2018-66-8) + L-Valine methyl ester (4070-48-8) → Z-Leu-Val (7801-70-9)

Guidance literature:

With tetrahydrofuran; dicyclohexyl-carbodiimide; Behandeln einer Loesung des Reaktionsprodukts in Dioxan und wenig Aceton;

DOI:10.1246/bcsj.31.88

upstream raw materials:

Z-Leu-OH

L-Valine methyl ester

(S)-benzyl (1-azido-4-methyl-1-oxopentan-2-yl)carbamate

Z-Leu-Val-OMe

Downstream raw materials:

N-[N-(N-benzyloxycarbonyl-L-leucyl)-L-valyl]-L-glutamic acid diethyl ester

N-benzyloxycarbonyl-L-leucyl=>L-valyl=>L-phenylalanine benzyl ester

N-[N-(N-benzyloxycarbonyl-L-leucyl)-L-valyl]-L-glutamic acid dibenzyl ester

L-leucyl-L-valine