N-benzylpyridin-4-amine

Base Information

• Chemical Name: N-benzylpyridin-4-amine
• CAS No.: 13556-71-3
• Molecular Formula: C12H12N2
• Molecular Weight: 184.241
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40354559
• Nikkaji Number: J1.284.642H
• Wikidata: Q82132783
• Mol file: 13556-71-3.mol

Synonyms:N-benzylpyridin-4-amine;4-Benzylaminopyridine;13556-71-3;benzyl-pyridin-4-yl-amine;Benzyl-pyridin-4-ylamine;ChemDiv2_003360;benzylpyridin-4-ylamine;4-(benzylamino)pyridine;SCHEMBL2126955;DTXSID40354559;LCUREJHJUJCKQS-UHFFFAOYSA-N;HMS1378I16;STK386815;AKOS005431350;SB52392;BS-26476;AM20050793;CS-0445424;FT-0650964;EN300-53430;A806953;J-006719;Z359298544

Chemical Property of N-benzylpyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.000163mmHg at 25°C
• Melting Point: 108-109.5 °C
• Refractive Index: 1.636
• Boiling Point: 330.8 °C at 760 mmHg
• PKA: 8.23±0.26(Predicted)
• Flash Point: 153.8 °C
• PSA: 24.92000
• Density: 1.131 g/cm³
• LogP: 2.76670
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.100048391
• Heavy Atom Count: 14
• Complexity: 146

Purity/Quality:

99% HPLC ^*data from raw suppliers

N-Benzylpyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNC2=CC=NC=C2

Technology Process of N-benzylpyridin-4-amine

There total 18 articles about N-benzylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-aminopyridine (504-24-5) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-4-aminopyridine (13556-71-3)

Guidance literature:

With iron(II,III) oxide; potassium tert-butylate; In 1,4-dioxane; at 90 ℃; for 168h; Inert atmosphere;

DOI:10.1039/b901929d

Reference yield: 99.0%

4-iodopyridine (15854-87-2) + benzylamine (100-46-9) → N-benzyl-4-aminopyridine (13556-71-3)

Guidance literature:

With cesium acetate; copper; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201000708

Reference yield: 93.0%

4-bromopyridine hydrochloride (19524-06-2) + benzylamine (100-46-9) → N-benzyl-4-aminopyridine (13556-71-3)

Guidance literature:

With cesium acetate; copper; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201000708

upstream raw materials:

4-aminopyridine

benzaldehyde

4-Chloropyridine

benzylamine

Downstream raw materials:

N-benzyl-N',N'-dimethyl-N-[4]pyridyl-ethylenediamine

4-aminopyridine

N-benzyl-2-phenyl-N-(pyridin-4-yl)propanamide