4-Iodopyridine

Base Information

• Chemical Name: 4-Iodopyridine
• CAS No.: 15854-87-2
• Molecular Formula: C5H4IN
• Molecular Weight: 204.998
• Hs Code.: 29333990
• Mol file: 15854-87-2.mol

Synonyms:4-Iodo Pyridine;4-Lodopyridine;

Chemical Property of 4-Iodopyridine

Chemical Property:

• Appearance/Colour: White to off-white crystals
• Vapor Pressure: 0.217mmHg at 25°C
• Melting Point: 80 °C
• Refractive Index: 1.5290
• Boiling Point: 215.4 °C at 760 mmHg
• PKA: pK1:4.02(＋1) (20°C)
• Flash Point: 84.1 °C
• PSA: 12.89000
• Density: 1.957 g/cm³
• LogP: 1.68620
• Storage Temp.: Freezer
• Sensitive.: Light Sensitive
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.

Technology Process of 4-Iodopyridine

There total 9 articles about 4-Iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-Chloropyridine (626-61-9) → 4-iodopyridine (15854-87-2)

Guidance literature:

With acetyl chloride; sodium iodide; In acetonitrile; at 18 - 80 ℃; Microwave irradiation;

DOI:10.1021/jo9008386

Reference yield: 70.0%

4-aminopyridine (504-24-5) → 4-iodopyridine (15854-87-2)

Guidance literature:

4-aminopyridine; With tetrafluoroboric acid; sodium nitrite; at -10 ℃; for 0.5h;

With potassium iodide; In acetone;

DOI:10.1021/ol070011y

Reference yield: 51.0%

4-bromopyridin (1120-87-2) → 4-iodopyridine (15854-87-2)

Guidance literature:

4-bromopyridin; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 1.5h;

With iodine; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(00)00027-2

upstream raw materials:

4-aminopyridine

4-Chloropyridine

pyridine

hydrogen iodide

Downstream raw materials:

1-(4'-pyridyl)-4-pyridone

4-Ethoxyethynyl-pyridine

4-phenylselenenylpyridine

4-pyridylacetylene

Refernces

• 1、 Wolf, Christian,Tumambac, Gilbert E.,Villalobos, Cristina N.. "Acid-Mediated Halogen Exchange in Heterocyclic Arenes: A Highly Effective Iodination Method". . p. 1801 - 1804. Retrieved 2003.
• 2、 Spinner. "-". . p. 3855,3857. Retrieved 1963.
• 3、 Armstrong, David R.,Clegg, William,Hevia, Eva,Honeyman, Gordon W.,Kennedy, Alan R.,McLellan, Ross,Mulvey, Robert E.,Orr, Samantha A.,Parkinson, John A.,Ramsay, Donna L.,Robertson, Stuart D.,Towie, Stephen. "A regioselectively 1,1′,3,3′-tetrazincated ferrocene complex displaying core and peripheral reactivity". . p. 6510 - 6520. Retrieved 2020/07/15.
• 4、 Bonakdarzadeh, Pia,Topi?, Filip,Kalenius, Elina,Bhowmik, Sandip,Sato, Sota,Groessl, Michael,Knochenmuss, Richard,Rissanen, Kari. "DOSY NMR, X-ray Structural and Ion-Mobility Mass Spectrometric Studies on Electron-Deficient and Electron-Rich M6L4 Coordination Cages". supporting information. p. 6055 - 6061. Retrieved 2015/06/25.