N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Base Information

Chemical Name:N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester
CAS No.:200504-93-4
Molecular Formula:C₂₃H₃₄BrN₃O₇
Molecular Weight:544.443
Hs Code.:

N-<sup>t</sup>BOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Synonyms:N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Suppliers and Price of N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Chemical Property:

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Technology Process of N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

There total 7 articles about N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 200504-92-3
N-^tBOC-L-alanyl-N-methyl-O-methyl-D-tyrosyl-L-alanine methyl ester

: 200504-93-4
N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Guidance literature:: With bromine; In chloroform; at 5 ℃; for 3h;

Reference yield:

: 556-02-5,18875-48-4,25619-78-7,30704-25-7
tyrosine

: 200504-93-4
N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / HCl / 2 h / 0 °C

2: 49 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

3: 54 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

4: 90 percent / TFA / CHCl₃ / 2 h / 20 °C

5: 59 percent / BOP-Cl; Et₃N / CHCl₃ / 0 - 20 °C

6: 43 percent / EDC; HOBT; Et₃N / CH₂Cl₂ / 0 - 20 °C

7: 76 percent / Br₂ / CHCl₃ / 3 h / 5 °C

With hydrogenchloride; bromine; sodium hexamethyldisilazane; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; 1: Methylation / 2: Substitution / 3: Methylation / 4: Substitution / 5: Condensation / 6: Condensation / 7: Bromination;

Reference yield:

: 76757-90-9
N-(tert-butoxycarbonyl)-D-tyrosine methyl ester

: 200504-93-4
N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

2: 90 percent / TFA / CHCl₃ / 2 h / 20 °C

3: 59 percent / BOP-Cl; Et₃N / CHCl₃ / 0 - 20 °C

4: 43 percent / EDC; HOBT; Et₃N / CH₂Cl₂ / 0 - 20 °C

5: 76 percent / Br₂ / CHCl₃ / 3 h / 5 °C

With bromine; sodium hexamethyldisilazane; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; 1: Methylation / 2: Substitution / 3: Condensation / 4: Condensation / 5: Bromination;