ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

Base Information

• Chemical Name: ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate
• CAS No.: 1420880-45-0
• Molecular Formula: C₂₃H₂₁N₃O₂
• Molecular Weight: 375.407

Synonyms:ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

Chemical Property of ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

Chemical Property:

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Technology Process of ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

There total 7 articles about ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)-3-nitrobenzoate (1420880-44-9) → ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)benzoate (1420880-45-0)

Guidance literature:

With hydrogenchloride; tin(II) chloride hydrate; for 2.5h; Cooling with ice;

DOI:10.1002/jlcr.2956

Reference yield:

2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-carbonitrile (1420880-42-7) → ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)benzoate (1420880-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 7 h / Reflux

2: hydrogenchloride / methanol; ethyl acetate / 2 h / 20 °C

3: hydrogenchloride; tin(II) chloride hydrate / 2.5 h / Cooling with ice

With hydrogenchloride; tin(II) chloride hydrate; potassium carbonate; In methanol; ethyl acetate; acetonitrile;

DOI:10.1002/jlcr.2956

Reference yield:

2,3,5,6-tetra-[2H]-4-bromo toluene (112484-85-2) → ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)benzoate (1420880-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 2 h / Reflux

4.1: potassium carbonate / acetonitrile / 7 h / Reflux

5.1: hydrogenchloride / methanol; ethyl acetate / 2 h / 20 °C

6.1: hydrogenchloride; tin(II) chloride hydrate / 2.5 h / Cooling with ice

With pyridine; hydrogenchloride; N-Bromosuccinimide; tin(II) chloride hydrate; iodine; potassium carbonate; magnesium; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethyl acetate; acetonitrile; 1.1: |Grignard Reaction;

DOI:10.1002/jlcr.2956

upstream raw materials:

2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-carbonitrile

ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

2,3,5,6-tetra-[²H]-4-bromo toluene

Downstream raw materials:

ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo [d]imidazole-7-carboxylate

C₂₄H₁₆⁽²⁾H₄N₆O₃

ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

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