1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

Base Information

Chemical Name:1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol
CAS No.:76042-36-9
Molecular Formula:C₂₁H₃₀O₂S
Molecular Weight:346.534
Hs Code.:

Synonyms:1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

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Chemical Property of 1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

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Technology Process of 1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

There total 6 articles about 1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 693-03-8
n-butyl magnesium bromide

: 76043-08-8
2-[1-[1-(4-Methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanone

: 76042-36-9
1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

Guidance literature:: In diethyl ether; Ambient temperature;
DOI:10.1021/ja00547a015

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 76042-36-9
1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

2: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C

3: 70 percent / diethyl ether / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00547a015

Reference yield:

: 69563-32-2
1-(cyclopropylsulphanyl)-4-methoxybenzene

: 76042-36-9
1-Butyl-2-[1-[1-(4-methoxy-phenylsulfanyl)-cyclopropyl]-meth-(E)-ylidene]-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / N-chlorosuccinimide / benzene / 23 h / Ambient temperature

2: 56 percent / tert-butyllithium / diethyl ether; pentane / 0.5 h / -78 °C

3: 83 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

4: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C

5: 70 percent / diethyl ether / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; N-chloro-succinimide; tert.-butyl lithium; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; diethyl ether; pentane; benzene;
DOI:10.1021/ja00547a015