2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester

Base Information

• Chemical Name: 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester
• CAS No.: 873055-21-1
• Molecular Formula: C₁₃H₁₅N₃O₆
• Molecular Weight: 309.279
• Mol file: 873055-21-1.mol

Synonyms:2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester

Chemical Property of 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester

There total 3 articles about 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-methyl-3,5-dinitrobenzoic acid ethyl ester (854646-60-9) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester (873055-21-1)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 5h;

Reference yield:

ortho-methylbenzoic acid (118-90-1) → 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester (873055-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: nitric acid; sulfuric acid / 1.5 h / 0 - 30 °C

2.1: thionyl chloride / 4 h / Reflux

2.2: 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 5 h / 100 °C

With thionyl chloride; sulfuric acid; nitric acid; In N,N-dimethyl-formamide;

Reference yield:

3,5-dinitro-o-toluic acid (28169-46-2) → 2-(2-dimethylamino-vinyl)-3,5-dinitro-benzoic acid ethyl ester (873055-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 4 h / Reflux

1.2: 1 h / 20 °C

2.1: N,N-dimethyl-formamide / 5 h / 100 °C

With thionyl chloride; In N,N-dimethyl-formamide;

upstream raw materials:

2-methyl-3,5-dinitrobenzoic acid ethyl ester

N,N-dimethyl-formamide dimethyl acetal

ortho-methylbenzoic acid

3,5-dinitro-o-toluic acid

Downstream raw materials:

6-amino-1H-indole-4-carboxylic acid ethyl ester