(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

Base Information

Chemical Name:(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol
CAS No.:99560-26-6
Molecular Formula:C₁₂H₁₆ClNO₂
Molecular Weight:241.718
Hs Code.:

Synonyms:(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

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Technology Process of (E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

There total 1 articles about (E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 99560-38-0
(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propenal

: 99560-26-6
(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 5 ℃; for 3h;
DOI:10.1021/jo00350a098

Reference yield: 98.0%

: 99560-26-6
(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

: 407-25-0
trifluoroacetic anhydride

: 99560-27-7
Trifluoro-acetic acid (E)-3-{4-chloro-3-methoxy-5-[methyl-(2,2,2-trifluoro-acetyl)-amino]-phenyl}-2-methyl-allyl ester

Guidance literature:: With sodium carbonate; In diethyl ether; for 0.5h;
DOI:10.1021/jo00350a098

Reference yield:

: 99560-26-6
(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

: 99560-34-6
(E)-2-chloro-3-methoxy-N-methyl-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>benzamine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Na₂CO₃ / diethyl ether / 0.5 h

2: buffer / methanol / 1 h / Ambient temperature; pH 10

3: 65 percent / p-TsCl, 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) MeONa / 1.) MeOH, 5 min, 2.) MeOH, 22 h

5: 93 percent / K₂CO₃*1.5H₂O / methanol; H₂O / 16 h / Ambient temperature

With dmap; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; p-toluenesulfonyl chloride; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo00350a098