ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

Base Information

Chemical Name:ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate
CAS No.:1454273-48-3
Molecular Formula:C₂₇H₂₉F₄N₃O₄
Molecular Weight:535.539
Hs Code.:

Synonyms:ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

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Chemical Property of ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

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Technology Process of ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

There total 4 articles about ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1454273-47-2
ethyl 8-benzyl-3-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

: 27738-96-1
chlorocarbonyl isocyanate

: 1454273-48-3
ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 40110-55-2
ethyl 2-(1-benzylpiperidine-4-ylidene)acetate

: 1454273-48-3
ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; 1,4-dioxane / 20 °C / Cooling with ice

1.2: 15 h / 20 - 80 °C

2.1: acetic acid / toluene / 12 h / 70 °C

3.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; acetic acid; In 1,4-dioxane; dichloromethane; toluene; mineral oil;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1454273-48-3
ethyl 8-benzyl-3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)ureido)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

1.2: 0.5 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: sodium hydride / mineral oil; 1,4-dioxane / 20 °C / Cooling with ice

2.2: 15 h / 20 - 80 °C

3.1: acetic acid / toluene / 12 h / 70 °C

4.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; mineral oil;