(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate
CAS No.:1454273-45-0
Molecular Formula:C₃₁H₃₄F₄N₄O₅
Molecular Weight:618.628
Hs Code.:

(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Synonyms:(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

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Chemical Property of (R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

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Technology Process of (R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

There total 9 articles about (R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1454273-44-9
(R)-tert-butyl (2-(1'-benzyl-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

: 1454273-45-0
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Guidance literature:: With palladium on carbon; hydrogen; In methanol; for 15h;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1454273-45-0
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

1.2: 0.5 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: sodium hydride / mineral oil; 1,4-dioxane / 20 °C / Cooling with ice

2.2: 15 h / 20 - 80 °C

3.1: hydrogenchloride / ethanol; water / 15 h / 20 - 100 °C

4.1: sodium hydroxide / ethanol; water / 20 - 70 °C

5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h

6.1: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

7.1: hydrogen; palladium on carbon / methanol / 15 h

With hydrogenchloride; palladium on carbon; tetrabutylammomium bromide; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetone; mineral oil;

Reference yield:

: 40110-55-2
ethyl 2-(1-benzylpiperidine-4-ylidene)acetate

: 1454273-45-0
(R)-tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil; 1,4-dioxane / 20 °C / Cooling with ice

1.2: 15 h / 20 - 80 °C

2.1: hydrogenchloride / ethanol; water / 15 h / 20 - 100 °C

3.1: sodium hydroxide / ethanol; water / 20 - 70 °C

4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h

5.1: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

6.1: hydrogen; palladium on carbon / methanol / 15 h

With hydrogenchloride; palladium on carbon; tetrabutylammomium bromide; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetone; mineral oil;