6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine

Base Information

• Chemical Name: 6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
• CAS No.: 1018480-91-5
• Molecular Formula: C₁₆H₁₄ClN₃O₂S₂
• Molecular Weight: 379.891

Synonyms:6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine

Chemical Property of 6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine

Chemical Property:

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Technology Process of 6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine

There total 1 articles about 6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-Aminomethylthiophene (27757-85-3) + 4,6-dichloro-2-(4-(methylsulfonyl)phenyl)pyrimidine (83217-48-5) → 6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine (1018480-91-5)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmc.2007.11.079

Reference yield: 85.0%

6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine (1018480-91-5) → 6-fluoro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 140 ℃; for 1h;

DOI:10.1007/s43440-020-00124-z

Reference yield: 83.0%

6-chloro-2-(4-(methylsulfonyl)phenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine (1018480-91-5) + diethylamine (109-89-7) → C20H24N4O2S2 (1018481-02-1)

Guidance literature:

at 100 ℃; for 144h;

DOI:10.1016/j.bmc.2007.11.079

upstream raw materials:

2-Aminomethylthiophene

4,6-dichloro-2-(4-(methylsulfonyl)phenyl)pyrimidine

Downstream raw materials:

C₁₉H₂₂N₄O₂S₂

C₂₀H₂₄N₄O₂S₂

C₁₆H₁₅N₃O₃S₂

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