tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate
CAS No.:912369-48-3
Molecular Formula:C₁₇H₂₅N₃O₄
Molecular Weight:335.403
Hs Code.:

Synonyms:tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

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Chemical Property of tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

There total 4 articles about tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912369-47-2
tert-butyl (3S)-3-[4-(aminocarbonyl)-2-nitrophenoxy]piperidine-1-carboxylate

: 912369-48-3
tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 12h;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 912369-48-3
tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

2.1: ammonia / dichloromethane / 0.33 h / -78 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 12 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h

With oxalyl dichloride; ammonia; hydrogen; sodium hydride; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 400-94-2
4-fluoro-3-nitrobenzoyl chloride

: 912369-48-3
tert-butyl (3S)-3-[2-amino-4-(aminocarbonyl)phenoxy]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / dichloromethane / 0.33 h / -78 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h

With ammonia; hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;