2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester
• CAS No.: 500361-30-8
• Molecular Formula: C₃₇H₄₁NO₈
• Molecular Weight: 627.734
• Mol file: 500361-30-8.mol

Synonyms:2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester

Chemical Property of 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester

There total 7 articles about 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2,2-dimethylpropanoic anhydride (1538-75-6) + 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3-hydroxy-2-methyl-1H-pyridin-4-one (500361-29-5) → 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester (500361-30-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1021/ja027175o

Reference yield:

3-benzyloxy-2-methyl-1H-pyridin-4-one (61160-18-7) → 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester (500361-30-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hexamethyldisilazane; (NH₄)2SO₄ / 2 h / Heating

1.2: 70 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 24 h / 20 °C

2.1: 30 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

3.1: 100 percent / 28percent aq. NH₄OH / methanol / 3 h / 20 °C

4.1: 77 percent / pyridine / 2 h / 20 °C

5.1: 61 percent / iPr₂EtN / tetrahydrofuran / 15 h / 20 °C

With pyridine; ammonium sulfate; hydrogen; N-ethyl-N,N-diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1021/ja027175o

Reference yield:

1,3,5-tri-O-acetyl-2-deoxyribose (4594-52-9,96291-74-6,96291-75-7) → 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester (500361-30-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hexamethyldisilazane; (NH₄)2SO₄ / 2 h / Heating

1.2: 70 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 24 h / 20 °C

2.1: 30 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

3.1: 100 percent / 28percent aq. NH₄OH / methanol / 3 h / 20 °C

4.1: 77 percent / pyridine / 2 h / 20 °C

5.1: 61 percent / iPr₂EtN / tetrahydrofuran / 15 h / 20 °C

With pyridine; ammonium sulfate; hydrogen; N-ethyl-N,N-diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1021/ja027175o

upstream raw materials:

2,2-dimethylpropanoic anhydride

1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3-hydroxy-2-methyl-1H-pyridin-4-one

1,3,5-tri-O-acetyl-2-deoxyribose

3-benzyloxy-2-methyl-1H-pyridin-4-one