3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Base Information

Chemical Name:3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one
CAS No.:96254-96-5
Molecular Formula:C₂₅H₃₄N₂O₅
Molecular Weight:442.555
Hs Code.:

Synonyms:3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

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Chemical Property of 3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

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Technology Process of 3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

There total 6 articles about 3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85176-61-0
1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

: 96254-96-5
3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 10h; under 3750.3 Torr; Ambient temperature;
DOI:10.1021/jm00167a033

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 96254-96-5
3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / thionyl chloride / CH₂Cl₂ / 1 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature

4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

5: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

6: 2 h / 90 - 95 °C

7: H₂ / Pd/C / acetic acid / 10 h / 3750.3 Torr / Ambient temperature

With hydrogenchloride; thionyl chloride; potassium tert-butylate; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid;
DOI:10.1021/jm00167a033

Reference yield:

: 73942-87-7
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

: 96254-96-5
3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

2: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

3: 2 h / 90 - 95 °C

4: H₂ / Pd/C / acetic acid / 10 h / 3750.3 Torr / Ambient temperature

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In acetic acid;
DOI:10.1021/jm00167a033