1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Base Information

Chemical Name:1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane
CAS No.:85176-61-0
Molecular Formula:C₂₅H₃₂N₂O₅
Molecular Weight:440.539
Hs Code.:

Synonyms:1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Suppliers and Price of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

There total 6 articles about 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3490-06-0
N-methylhomoveratrylamine

: 85176-62-1
1-(7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl)-2-chloro-ethane

: 85176-61-0
1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Guidance literature:

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 85176-61-0
1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / thionyl chloride / CH₂Cl₂ / 1 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature

4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

5: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

6: 2 h / 90 - 95 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm00167a033

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 85176-61-0
1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-2-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-ethane

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

2: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature

3: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

5: 2 h / 90 - 95 °C

With hydrogenchloride; potassium tert-butylate; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm00167a033