7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

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Chemical Name:7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether
CAS No.:740809-75-0
Molecular Formula:C₄₈H₆₆NO₆P
Molecular Weight:784.029
Hs Code.:

Synonyms:7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

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Chemical Property of 7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

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Technology Process of 7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

There total 13 articles about 7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 408512-85-6
7α-[6-(N-(2-(tert-butyldimethylsilanyloxy)-ethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

: 740809-75-0
7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja017344p

Reference yield:

: 408512-84-5
3,17β-bis(2-tetrahydropyranyloxy)-7α-(6-bromohexan-1-yl)-estra-1,3,5(10)triene

: 740809-75-0
7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: NaH; tetrabutylammonium bromide / benzene / 60 °C

2: tetrabutylammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1016/j.bmcl.2004.04.064

Reference yield:

: 408512-83-4
6-((7R,13S,14S,17S)-13-methyl-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)hexan-1-ol

: 740809-75-0
7α-[6-(N-(2-hydroxyethyl)-diphenylphosphinamido)-hexan-1-yl]-estra-1,3,5(10)triene-3,17β-bis-2-tetrahydropyranyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylethyl amine / tetrahydrofuran

2: LiBr; TEA / dimethylformamide / 60 °C

3: NaH; tetrabutylammonium bromide / benzene / 60 °C

4: tetrabutylammonium fluoride / tetrahydrofuran

With TEA; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmcl.2004.04.064