408512-85-6Relevant academic research and scientific papers
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells
Mitra, Kaushik,Marquis, John C.,Hillier, Shawn M.,Rye, Peter T.,Zayas, Beatriz,Lee, Annie S.,Essigmann, John M.,Croy, Robert G.
, p. 1862 - 1863 (2002)
We describe a novel strategy to increase the selective toxicity of genotoxic compounds. The strategy involves the synthesis of bifunctional molecules capable of forming DNA adducts that have high affinity for specific proteins in target cells. It is propo
Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents
Sharma,Marquis,Dinaut, A. Nicole,Hillier,Fedeles,Rye,Essigmann,Croy
, p. 3829 - 3833 (2007/10/03)
A series of bifunctional compounds was prepared consisting of 17β estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and
