4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

Base Information

Chemical Name:4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran
CAS No.:1357016-37-5
Molecular Formula:C₂₈H₂₆O₆
Molecular Weight:458.511
Hs Code.:

Synonyms:4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

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Chemical Property of 4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

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Technology Process of 4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

There total 8 articles about 4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1357016-35-3
1-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)prop-2-yn-1-ol

: 824-94-2
p-methoxybenzyl chloride

: 1357016-37-5
4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

Guidance literature:: 1-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)prop-2-yn-1-ol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.75h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo202366c

Reference yield: 36.0%

: C₂₀H₁₆O₅

: 824-94-2
p-methoxybenzyl chloride

: 1357016-37-5
4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

Guidance literature:: C₂₀H₁₆O₅; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.75h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo3010952

Reference yield:

: 95125-08-9
4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carboxaldehyde

: 1357016-37-5
4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)prop-2-yn-1-yl)-2-(4-methoxyphenyl)benzofuran

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo202366c