6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

Base Information

Chemical Name:6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one
CAS No.:1357016-41-1
Molecular Formula:C₂₈H₂₆O₇
Molecular Weight:474.51
Hs Code.:

Synonyms:6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

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Chemical Property of 6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

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Technology Process of 6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

There total 9 articles about 6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1357016-40-0
4,6-dimethoxy-3-(1-((4-methoxybenzyl)oxy)propa-1,2-dien-1-yl)-2-(4-methoxyphenyl)benzofuran

: 1357016-41-1
6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

Guidance literature:: With 3,3-dimethyldioxirane; In acetone; at 0 ℃; Inert atmosphere;
DOI:10.1021/jo202366c

Reference yield:

: 1160457-28-2
4,6-dimethoxy-2-(4-methoxyphenyl)-3-vinylbenzofuran

: 1357016-41-1
6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: N-benzyl-trimethylammonium hydroxide / methanol; dimethyl sulfoxide / 1 h / 40 °C / Inert atmosphere

5.1: 3,3-dimethyldioxirane / acetone / 0 °C / Inert atmosphere

With 4-methyl-morpholine; osmium(VIII) oxide; 3,3-dimethyldioxirane; N-benzyl-trimethylammonium hydroxide; sodium hydride; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;
DOI:10.1021/jo202366c

Reference yield:

: 1357016-35-3
1-(4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl)prop-2-yn-1-ol

: 1357016-41-1
6,8-dimethoxy-1-((4-methoxybenzyl)oxy)-3a-(4-methoxyphenyl)-3,3a-dihydro-2H-cyclopenta[b]benzofuran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: N-benzyl-trimethylammonium hydroxide / methanol; dimethyl sulfoxide / 1 h / 40 °C / Inert atmosphere

3.1: 3,3-dimethyldioxirane / acetone / 0 °C / Inert atmosphere

With 3,3-dimethyldioxirane; N-benzyl-trimethylammonium hydroxide; sodium hydride; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/jo202366c