N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide

Base Information

• Chemical Name: N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide
• CAS No.: 117897-73-1
• Molecular Formula: C₁₁H₇F₅N₂O
• Molecular Weight: 278.181
• Mol file: 117897-73-1.mol

Synonyms:N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide

Chemical Property of N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide

There total 3 articles about N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-aminophenylacetonitrile (3544-25-0) + 2,2,3,3,3-pentafluoropropanoic anhydride (356-42-3) → N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide (117897-73-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm00083a021

Reference yield:

p-aminophenylacetonitrile (3544-25-0) + pentafluoropropionic acid (422-64-0) → N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide (117897-73-1)

Guidance literature:

With 1-ethoxyacetylene; In ethyl acetate; at 85 ℃; for 15h;

DOI:10.1021/jm00121a003

Reference yield:

p-aminophenylacetonitrile (3544-25-0) + 2,2,3,3,3-pentafluoropropionyl chloride (422-59-3) → N-(4-Cyanomethyl-phenyl)-2,2,3,3,3-pentafluoro-propionamide (117897-73-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

DOI:10.1021/jm00121a003

upstream raw materials:

p-aminophenylacetonitrile

pentafluoropropionic acid

2,2,3,3,3-pentafluoropropanoic anhydride

2,2,3,3,3-pentafluoropropionyl chloride

Downstream raw materials:

2,2,3,3,3-pentafluoro-N-[4-(1H-tetrazol-5-ylmethyl)phenyl]propanamide