356-42-3

Basic information

• Product Name: Perfluoropropionic anhydride
• Synonyms: 1,1,2,2,2-Pentafluoropropanoic anhydride;2,2,3,3,3-Pentafluoropropionic acid anhydride;Perfluoropropionic acid anhydride;Propanoic acid, pentafluoro-, anhydride;Propionic acid, pentafluoro-, anhydride;PFAA;PERFLUOROPROPIONIC ANHYDRIDE;PFPA
• CAS NO: 356-42-3
• Molecular Formula: C₆F₁₀O₃
• Molecular Weight: 310.05
• EINECS: 206-604-2
• Product Categories: Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Enzymes;-Glucuronidase;-Glucuronidase Drug Analysis Bundle;Inhibitors;Organic Building Blocks;Acylation Reagent;Small molecule;Acylation (GC Derivatizing Reagents);Analytical Chemistry;GC Derivatizing Reagents;organofluorine compounds;Analytical and Industrial Enzymes;PFPA - Pentafluoropropionic anhydride;βand Substrates;Biochemicals and Reagents;Building Blocks
• Mol File: 356-42-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: -43
• Boiling Point: 69-70 °C735 mm Hg(lit.)
• Flash Point: None
• Appearance: Clear colorless/Liquid
• Density: 1.571 g/mL at 25 °C(lit.)
• Vapor Pressure: 129mmHg at 25°C
• Refractive Index: 1.3
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 1806446
• CAS DataBase Reference: Perfluoropropionic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: Perfluoropropionic anhydride(356-42-3)
• EPA Substance Registry System: Perfluoropropionic anhydride(356-42-3)

Safety Data

• Hazard Codes: C
• Statements: 34-14
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• TSCA: T
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 356-42-3(Hazardous Substances Data)

Usage

Chemical Properties

Perfluoropropionic anhydride is clear colorless liquid

Uses

Different sources of media describe the Uses of 356-42-3 differently. You can refer to the following data:
1. Perfluoropropionic anhydride used in a GC-MS analysis of stereoisomer content of synthetic peptides.1 Also used in a GC-MS detection method for synephrine in dietary supplements.2
2. Pentafluoropropionic anhydride act as a derivatising agent of amines and alcohols. It is used in the in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluid, as derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detection and in simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography.
3. Pentafluoropropionic anhydride was used:in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluidas derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detectionin simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography

InChI:InChI=1/C6F10O3/c7-3(8,5(11,12)13)1(17)19-2(18)4(9,10)6(14,15)16

Upstream product

• 422-59-3 2,2,3,3,3-pentafluoropropionyl chloride 
• 422-64-0 pentafluoropropionic acid 
• 59239-87-1 bis(trifluoromethyl)phosphinous pentafluoropropionic anhydride 

Downstream Products

• 14814-99-4 2,2,3,3,3-pentafluoro-N-(o-tolyl)propanamide 
• 77774-26-6 2,2,3,3,3-Pentafluoro-propionic acid 2-[2-(2,2,3,3,3-pentafluoro-propionylamino)-ethyl]-phenyl ester 
• 13230-93-8 phenethylamine pentafluoropropionate 
• 378-72-3 1,1,1,2,2-pentafluoropentan-3-one 
• 426-65-3 ethyl Pentafluoropropionate 
• 422-64-0 pentafluoropropionic acid 
• 356-45-6 bis(pentafluoropropionyl)peroxide 
• 904700-80-7 tert-butyldiphenylsilyl 2-azido-3,6-di-O-benzyl-2-deoxy-4-O-pentafluoropropionyl-β-D-galactopyranoside 
• 904700-92-1 tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl-(1->3)-2-azido-6-O-benzyl-2-deoxy-4-O-pentafluoropropionyl-β-D-galactopyranoside 
• 911381-02-7 2,2,3,3,3-pentafluoro-N-(2-nitrophenyl)propanamide 
• 1449241-28-4 C₃₁H₃₁F₅O₆S 
• 1449241-35-3 C₃₁H₃₁F₅O₆S 

Relevant articles and documents

PROCESS FOR PRODUCING PERFLUORO ORGANIC PEROXIDE

To provide a process for safely producing a perfluoroacyl peroxide with good productivity. By supplying a perfluoroacyl halide-containing organic solvent solution, an aqueous solution of hydrogen peroxide or a metal peroxide, and an aqueous basic alkali metal compound solution to a tubular reactor to allow them to react with one another, in a flow rate ratio of, as represented by molar ratio of the compounds in the solutions, from 1.00 to 1.35 of the basic alkali metal compound and from 0.60 to 40 of hydrogen peroxide or the metal peroxide per 1 of the perfluoroacyl halide, the yield of a perfluoroacyl peroxide based on the material perfluoroacyl halide can be remarkably improved as compared with conventional technique.

REACTIONS OF PHOSPHITE ESTERS WITH THE ANHYDRIDES OF PERFLUORINATED CARBOXYLIC ACIDS: CALORIMETRY AND IR SPECTRA

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