13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.04,6]octadec-7-ene-4-carboxyric acid ethyl ester

Base Information

Chemical Name:13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester
CAS No.:922726-53-2
Molecular Formula:C₂₆H₃₂N₄O₈
Molecular Weight:528.562
Hs Code.:

Synonyms:13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester

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Chemical Property of 13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester

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Technology Process of 13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester

There total 5 articles about 13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 922726-52-1
4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-1-(hex-5-enyl-methyl-carbamoyl)-pyrrolidin-3-yl ester

: C₄H₄N₃PolS₃

: 922726-53-2
13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester

Guidance literature:: 4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-1-(hex-5-enyl-methyl-carbamoyl)-pyrrolidin-3-yl ester; In 1,2-dichloro-ethane; Heating / reflux;

C₄H₄N₃PolS₃; In 1,2-dichloro-ethane; for 2h;

Reference yield:

: 746657-36-3,213316-32-6,259221-73-3
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate

: 922726-53-2
13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; toluene / 1 h

4.2: 20 °C

5.1: 1,2-dichloro-ethane / Heating / reflux

5.2: 2 h

With di-isopropyl azodicarboxylate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 922726-51-0
4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidin-3-yl ester

: 922726-53-2
13-methyl-17-(4-nitro-benzoyloxy)-2,14-dioxo-3,13,15-triazatricyclo-[13.3.0.0*4,6*]octadec-7-ene-4-carboxyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; toluene / 1 h

1.2: 20 °C

2.1: 1,2-dichloro-ethane / Heating / reflux

2.2: 2 h

With sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;