Cyclopropanecarboxylic acid, 2-ethenyl-1-[[[(2S,4S)-1-[(5-hexen-1-ylmethylamino)carbonyl]-4-[(4-nitro benzoyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-, ethyl ester, (1R,2S)-

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 2-ethenyl-1-[[[(2S,4S)-1-[(5-hexen-1-ylmethylamino)carbonyl]-4-[(4-nitro benzoyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-, ethyl ester, (1R,2S)-
CAS No.:922726-52-1
Molecular Formula:C28H36N4O8
Molecular Weight:556.616
Hs Code.:

Cyclopropanecarboxylic acid,
2-ethenyl-1-[[[(2S,4S)-1-[(5-hexen-1-ylmethylamino)carbonyl]-4-[(4-nitro
benzoyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-, ethyl ester, (1R,2S)-

Synonyms:

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Chemical Property of Cyclopropanecarboxylic acid, 2-ethenyl-1-[[[(2S,4S)-1-[(5-hexen-1-ylmethylamino)carbonyl]-4-[(4-nitro benzoyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-, ethyl ester, (1R,2S)-

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Cyclopropanecarboxylic acid, 2-ethenyl-1-[[[(2S,4S)-1-[(5-hexen-1-ylmethylamino)carbonyl]-4-[(4-nitro benzoyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-, ethyl ester, (1R,2S)-

There total 6 articles about Cyclopropanecarboxylic acid, 2-ethenyl-1-[[[(2S,4S)-1-[(5-hexen-1-ylmethylamino)carbonyl]-4-[(4-nitro benzoyl)oxy]-2-pyrrolidinyl]carbonyl]amino]-, ethyl ester, (1R,2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-44-5
phosgene

: 862175-17-5
N-methylhex-5-en-1-amine hydrochloride

: 922726-51-0
4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidin-3-yl ester

: 922726-52-1
4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-1-(hex-5-enyl-methyl-carbamoyl)-pyrrolidin-3-yl ester

Guidance literature:: phosgene; 4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidin-3-yl ester; With sodium hydrogencarbonate; In tetrahydrofuran; toluene; for 1h;

N-methylhex-5-en-1-amine hydrochloride; With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 746657-36-3,213316-32-6,259221-73-3
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate

: 922726-52-1
4-nitro-benzoic acid (3S,5S)-5-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-1-(hex-5-enyl-methyl-carbamoyl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; toluene / 1 h

4.2: 20 °C

With di-isopropyl azodicarboxylate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;