(E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

Base Information

Chemical Name:(E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester
CAS No.:757975-99-8
Molecular Formula:C₃₉H₄₃N₃O₄
Molecular Weight:617.788
Hs Code.:

Synonyms:(E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

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Chemical Property of (E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

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Technology Process of (E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

There total 9 articles about (E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 757976-47-9
1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

: 14447-01-9
benzyl prop-2-ynoate

: 757975-99-8
(E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; for 30h;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 757976-46-8
tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate

: 757975-99-8
(E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 84 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(diethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 99 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

3.1: 66 percent / N-methylmorpholine / tetrahydrofuran / 30 h

With 4-methyl-morpholine; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 757976-22-0
1-[(biphenyl-3-yl)amino]cyclohexanecarboxylic acid

: 757975-99-8
(E)-3-[4-((S)-2-{[1-(Biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 84 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(diethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 99 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

3.1: 66 percent / N-methylmorpholine / tetrahydrofuran / 30 h

With 4-methyl-morpholine; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032