1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

Base Information

Chemical Name:1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide
CAS No.:757976-47-9
Molecular Formula:C₂₉H₃₅N₃O₂
Molecular Weight:457.616
Hs Code.:

Synonyms:1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

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Chemical Property of 1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

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Technology Process of 1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

There total 9 articles about 1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 757975-81-8
1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

: 757976-47-9
1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃; for 6h;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 757976-46-8
tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate

: 757976-47-9
1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 84 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(diethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 99 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 757976-22-0
1-[(biphenyl-3-yl)amino]cyclohexanecarboxylic acid

: 757976-47-9
1-[(biphenyl-3-yl)amino]-N-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / CH₂Cl₂

1.2: 84 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(diethylamino)propyl]carbodiimide HCl / dimethylformamide

2.1: 99 percent / H₂ / Pd-C / ethanol / 6 h / 40 °C

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032