(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Base Information

Chemical Name:(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester
CAS No.:160885-41-6
Molecular Formula:C₄₂H₄₅N₃O₈
Molecular Weight:719.835
Hs Code.:

(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Synonyms:(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Chemical Property of (R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Technology Process of (R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

There total 4 articles about (R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55322-23-1
N-Benzyloxy-L-alanin-tert.-butylester

: 142635-71-0
D-(N^α-Fmoc,N^δ-Cbz)-Piz-Cl

: 160885-41-6
(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 0 ℃; Yield given;
DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

: 55322-21-9
(S)-N-benzyloxy-alanine Me Ester

: 160885-41-6
(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1M NaOH / tetrahydrofuran / 0 °C

2: H₂SO₄ / CH₂Cl₂; dioxane

3: 12percent aq. NaHCO₃ / CH₂Cl₂ / 0 °C

With sodium hydroxide; sulfuric acid; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

: 54837-16-0
(S)-N-benzyloxy-alanine

: 160885-41-6
(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂SO₄ / CH₂Cl₂; dioxane

2: 12percent aq. NaHCO₃ / CH₂Cl₂ / 0 °C

With sulfuric acid; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1016/S0040-4039(00)78375-4