1,2-Pyridazinedicarboxylic acid, 3-[[[(1S)-1-carboxyethyl](phenylmethoxy)amino]carbonyl]tetrahydro-, 2-(9H-fluoren-9-ylmethyl) 1-(phenylmethyl) ester, (3R)-

Base Information

• Chemical Name: 1,2-Pyridazinedicarboxylic acid, 3-[[[(1S)-1-carboxyethyl](phenylmethoxy)amino]carbonyl]tetrahydro-, 2-(9H-fluoren-9-ylmethyl) 1-(phenylmethyl) ester, (3R)-
• CAS No.: 160885-39-2
• Molecular Formula: C38H37N3O8
• Molecular Weight: 663.727
• Mol file: 160885-39-2.mol

Synonyms:

Chemical Property of 1,2-Pyridazinedicarboxylic acid, 3-[[[(1S)-1-carboxyethyl](phenylmethoxy)amino]carbonyl]tetrahydro-, 2-(9H-fluoren-9-ylmethyl) 1-(phenylmethyl) ester, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Pyridazinedicarboxylic acid, 3-[[[(1S)-1-carboxyethyl](phenylmethoxy)amino]carbonyl]tetrahydro-, 2-(9H-fluoren-9-ylmethyl) 1-(phenylmethyl) ester, (3R)-

There total 6 articles about 1,2-Pyridazinedicarboxylic acid, 3-[[[(1S)-1-carboxyethyl](phenylmethoxy)amino]carbonyl]tetrahydro-, 2-(9H-fluoren-9-ylmethyl) 1-(phenylmethyl) ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (160885-41-6) → (R)-3-[Benzyloxy-((S)-1-carboxy-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (160885-39-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

(S)-N-benzyloxy-alanine Me Ester (55322-21-9) → (R)-3-[Benzyloxy-((S)-1-carboxy-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (160885-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1M NaOH / tetrahydrofuran / 0 °C

2: H₂SO₄ / CH₂Cl₂; dioxane

3: 12percent aq. NaHCO₃ / CH₂Cl₂ / 0 °C

4: 93 percent / TFA / CH₂Cl₂

With sodium hydroxide; sulfuric acid; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

N-Benzyloxy-L-alanin-tert.-butylester (55322-23-1) → (R)-3-[Benzyloxy-((S)-1-carboxy-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (160885-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 12percent aq. NaHCO₃ / CH₂Cl₂ / 0 °C

2: 93 percent / TFA / CH₂Cl₂

With sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)78375-4

upstream raw materials:

(R)-3-[Benzyloxy-((S)-1-tert-butoxycarbonyl-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

N-Benzyloxy-L-alanin-tert.-butylester

(S)-N-benzyloxy-alanine Me Ester

(S)-N-benzyloxy-alanine

Downstream raw materials:

3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

C₅₁H₇₁N₇O₁₂Si

C₆₀H₆₈N₈O₁₃

C₆₆H₈₁N₇O₁₄Si