1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1616491-36-1
Molecular Formula:C₁₉H₁₄INO₆
Molecular Weight:479.228
Hs Code.:

Synonyms:1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 10 articles about 1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1616491-35-0
6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1616491-36-1
1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2014.05.028

Reference yield:

: 89-56-5
5-Methylsalicylic acid

: 1616491-36-1
1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / Reflux

2: Perbenzoic acid; N-Bromosuccinimide / tetrachloromethane / Reflux

3: ammonia / methanol / 2 h / 70 °C

4: ethanol; diethyl ether / 0.25 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

6: water; hydrogenchloride / methanol / 2 h / Reflux

7: boron tribromide / dichloromethane / 6 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; ammonia; water; boron tribromide; potassium carbonate; In methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2014.05.028

Reference yield:

: 98165-65-2
methyl 5-(bromomethyl)-2-methoxybenzoate

: 1616491-36-1
1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / methanol / 2 h / 70 °C

2: ethanol; diethyl ether / 0.25 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

4: water; hydrogenchloride / methanol / 2 h / Reflux

5: boron tribromide / dichloromethane / 6 h / 20 °C

With hydrogenchloride; ammonia; water; boron tribromide; potassium carbonate; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.028