2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

Base Information

Chemical Name:2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide
CAS No.:1025882-98-7
Molecular Formula:C₂₃H₂₃F₃N₂O₆S
Molecular Weight:512.507
Hs Code.:

Synonyms:2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

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Chemical Property of 2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

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Technology Process of 2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

There total 14 articles about 2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(3-isopropoxy)benzoyl-4-aminomethyl-6,7-dimethoxy-isoquinoline hydrochloride

: 1648-99-3
2,2,2-Trifluoroethanesulfonyl chloride

: 1025882-98-7
2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 1h;

Reference yield:

: 798563-45-8
1-(3-isopropoxybenzyl)-4-chloromethyl-6,7-dimethoxyisoquinoline

: 1025882-98-7
2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / dimethyl sulfoxide / 1 h / 65 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 1 h / 2068.65 Torr

3: selenium(IV) oxide / ethyl acetate / 1.5 h / Heating / reflux

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: triethylamine / dichloromethane / 1 h / -78 °C

With selenium(IV) oxide; sodium azide; hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 798563-22-1
1-(3-isopropoxybenzyl)-6,7-dimethoxyisoquinoline-4-methanol

: 1025882-98-7
2,2,2-trifluoro-ethanesulfonic acid [1-(3-methoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.33 h / 0 °C

1.2: 20 °C

2.1: sodium azide / dimethyl sulfoxide / 1 h / 65 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 1 h / 2068.65 Torr

4.1: selenium(IV) oxide / ethyl acetate / 1.5 h / Heating / reflux

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / -78 °C

With selenium(IV) oxide; sodium azide; hydrogen; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate;