Technology Process of 1-(3-isopropoxybenzyl)-4-azidomethyl-6,7-dimethoxyisoquinoline
There total 10 articles about 1-(3-isopropoxybenzyl)-4-azidomethyl-6,7-dimethoxyisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide;
In
dimethyl sulfoxide;
at 65 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium / ethanol; toluene
1.2: 80 °C
2.1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane
4.1: phosphorus pentachloride / dichloromethane
5.1: sulfur / 165 °C / neat (no solvent)
6.1: lithium aluminium tetrahydride / tetrahydrofuran
7.1: methanesulfonyl chloride; triethylamine / dichloromethane
8.1: sodium azide / dimethyl sulfoxide / 50 °C
With
hydrogenchloride; lithium aluminium tetrahydride; sodium azide; phosphorus pentachloride; palladium on activated charcoal; hydrogen; sodium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene;
4.1: Bischler-Napieralski reaction;
DOI:10.1016/j.bmcl.2011.09.009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr
2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane
3: phosphorus pentachloride / dichloromethane
4: sulfur / 165 °C / neat (no solvent)
5: lithium aluminium tetrahydride / tetrahydrofuran
6: methanesulfonyl chloride; triethylamine / dichloromethane
7: sodium azide / dimethyl sulfoxide / 50 °C
With
hydrogenchloride; lithium aluminium tetrahydride; sodium azide; phosphorus pentachloride; palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
3: Bischler-Napieralski reaction;
DOI:10.1016/j.bmcl.2011.09.009
