N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

Base Information

Chemical Name:N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide
CAS No.:1455457-34-7
Molecular Formula:C₂₅H₂₃F₉N₂O₂
Molecular Weight:554.455
Hs Code.:

Synonyms:N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

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Chemical Property of N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

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Technology Process of N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

There total 4 articles about N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.8%

: 1221771-61-4
N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

: 1455457-34-7
N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

Guidance literature:: With pyridine-2-carboxylic acid, Ag(II) chelate; water; trifluoroacetic acid; In acetonitrile; at 0 ℃;

Reference yield:

: 34598-49-7
5-Bromo-1-indanone

: 1455457-34-7
N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2: sodium tetrahydroborate; nickel(II) chloride dihydrate; methanol / 0.5 h / Cooling with ice

3: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 2 h / 100 °C / Inert atmosphere

4: trifluoroacetic acid; pyridine-2-carboxylic acid, Ag(II) chelate; water / acetonitrile / 0 °C

With methanol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium tetrahydroborate; nickel(II) chloride dihydrate; pyridine-2-carboxylic acid, Ag(II) chelate; hydroxylamine hydrochloride; water; sodium acetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; In methanol; toluene; acetonitrile;

Reference yield:

: 185122-63-8
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1455457-34-7
N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; nickel(II) chloride dihydrate; methanol / 0.5 h / Cooling with ice

2: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 2 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid; pyridine-2-carboxylic acid, Ag(II) chelate; water / acetonitrile / 0 °C

With methanol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium tetrahydroborate; nickel(II) chloride dihydrate; pyridine-2-carboxylic acid, Ag(II) chelate; water; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; In toluene; acetonitrile;