(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

Base Information

Chemical Name:(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate
CAS No.:150943-39-8
Molecular Formula:C₁₉H₂₀ClN₅O₅
Molecular Weight:433.851
Hs Code.:

Synonyms:(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

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Technology Process of (R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

There total 2 articles about (R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150943-37-6
(R)-1-((tert-butyldiphenylsilyl)oxy)-4-chloro-2-(methoxymethoxy)butane

: 150943-39-8
(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / Bu₄NF / acetonitrile / 20 h / Ambient temperature

2: 1.) BSA, TMS triflate / 1.) a) 1,2-dichloroethane, RT, 1.5 h, b) 15 min , 2.) acetonitrile, RT, 30 min

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; In acetonitrile;
DOI:10.1021/jm00035a018

Reference yield:

: 3056-33-5
2,9-diacetylguanine

: 150943-38-7
(R)-4-chloro-2-(methoxymethoxy)butyl benzoate

: 150943-39-8
(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

: (R)-2-((2-acetamido-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-chlorobutyl benzoate

Guidance literature:: With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) a) 1,2-dichloroethane, RT, 1.5 h, b) 15 min , 2.) acetonitrile, RT, 30 min;
DOI:10.1021/jm00035a018

Reference yield:

: 150943-39-8
(R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-chlorobutyl benzoate

: (R)-2-((2-acetamido-1,6-dihydro-6-oxo-7H-purin-7-yl)methoxy)-4-iodobutyl benzoate

: (R)-2-((2-acetamido-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-iodobutyl benzoate

Guidance literature:: With sodium iodide; In butanone; at 80 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jm00035a018