3056-33-5Relevant articles and documents
Voltammetric study of the affinity of divalent heavy metals for guanine-functionalized iron oxide nanoparticles
Sawan, Simona,Hamze, Khalil,Youssef, Ali,Boukarroum, Rayyan,Bouhadir, Kamal,Errachid, Abdelhamid,Maalouf, Rita,Jaffrezic-Renault, Nicole
, p. 229 - 240 (2021/02/12)
In this study, a novel nanobiomaterial based on (3-aminopropyl)triethoxysilane (APTES)-coated iron oxide (Fe3O4) nanoparticles functionalized with newly synthesized guanine hydrazide (GH) was elaborated. A boron-doped diamond electrode coated with GH-APTES–Fe3O4 nanoparticles was used to assess the interaction of heavy metal ions with guanine hydrazide. The adsorption isotherms were electrochemically investigated and it was shown that the adsorption capacity of the nanoparticles towards heavy metals decreased in the following order: Cu2+ > Pb2+ > Cd2+. From the calibration curves, the sensitivities of detection were as follows: 171.6 μA/μM for Cu(II), 156 μA/μM for Pb(II), and 101.4 μA/μM for Cd(II). Graphic abstract: [Figure not available: see fulltext.].
Small Molecules in the Cone Snail Arsenal
Neves, Jorge L. B.,Lin, Zhenjian,Imperial, Julita S.,Antunes, Agostinho,Vasconcelos, Vitor,Olivera, Baldomero M.,Schmidt, Eric W.
supporting information, p. 4933 - 4935 (2015/11/03)
Cone snails are renowned for producing peptide-based venom, containing conopeptides and conotoxins, to capture their prey. A novel small-molecule guanine derivative with unprecedented features, genuanine, was isolated from the venom of two cone snail species. Genuanine causes paralysis in mice, indicating that small molecules and not just polypeptides may contribute to the activity of cone snail venom.
Synthesis of some biologically active halogenopurines
Hu, Yu Lin,Liu, Xiang,Lu, Ming,Ge, Qiang,Liu, Xiao Bin
experimental part, p. 429 - 436 (2010/12/29)
A series of some biologically active halogenopurines were synthesized from commercially available guanine (1). The reaction of guanine with acetic anhydride yielded 2,9-diacetylguanine (2-1) by acetylation reaction. Further treatment of 2-1 with POCl3 by PEG-2000 phase transfer catalysis furnished the important compound 3a, then 2-amino-6-halogenopurines (3b-d) were obtained through chlorine-exchange halogenations between KX and 3a by TPPB phase transfer catalyst. Further, 2-halogenopurines (2-2a-d, 4-2a-d, 5a-d) were efficiently prepared from 2-amino-6-substituted purines (1, 3a, 4-1) via a diazotization catalyzed by their corresponding CuX, and some new compounds 2-2a, 2-2c, 2-2d, 4-2c, 4-2d, 5b, 5c and 5d have been discovered. The structures of synthesized compounds were mainly established on the basis of their elemental analysis, 1H NMR, as well as their mass spectral data. All the title compounds were screened for their antifungal activities, and some of the compounds showed promising activity.