benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

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Chemical Name:benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate
CAS No.:1427195-82-1
Molecular Formula:C₄₂H₅₃N₃O₁₃
Molecular Weight:807.895
Hs Code.:

Synonyms:benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

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Chemical Property of benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

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Technology Process of benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

There total 7 articles about benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 661480-98-4
4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoic acid

: 60421-20-7
benzyl 2-amino-2-methylpropionate hydrochloride

: 1427195-82-1
benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2012.11.041

Reference yield:

: 177736-20-8
4-(4-formylphenyl)butyric acid ethyl ester

: 1427195-82-1
benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / methanol; tetrahydrofuran / 5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

4: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

5: sodium hydride / tetrahydrofuran / 10 h / 0 °C / Reflux

6: hydrazine hydrate / isopropyl alcohol / 20 °C

7: benzyltri(n-butyl)ammonium chloride; sodium hydroxide / dichloromethane / 20 °C

8: palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

9: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; benzyltri(n-butyl)ammonium chloride; sodium hydride; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.11.041

Reference yield:

: 1370290-50-8
benzyl 4-(4-formylphenyl)butanoate

: 1427195-82-1
benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3: sodium hydride / tetrahydrofuran / 10 h / 0 °C / Reflux

4: hydrazine hydrate / isopropyl alcohol / 20 °C

5: benzyltri(n-butyl)ammonium chloride; sodium hydroxide / dichloromethane / 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; benzyltri(n-butyl)ammonium chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.11.041