60421-20-7

Basic information

• Product Name: H-Aib-OBzl
• Synonyms: 2-Methylalanine benzyl ester hydrochloride;Benzyl 2-amino-2-methylpropionate hydrochloride;Benzyl α-aminoisobutyrate hydrochloride;Benzyl alpha-aMinoisobutyrate hydrochloride;2-AMino-2-Methylpropanoic acid benzyl ester HCl salt;2-Amino-2-methylpropionic acid benzyl ester hydrochloride;alpha-Aminoisobutyric acid benzyl ester hydrochloride;Benzyl 2-amino-2-methylpropanoate HCl
• CAS NO: 60421-20-7
• Molecular Formula: C₁₁H₁₅NO₂*ClH
• Molecular Weight: 229.70324
• Product Categories: Alanine Derivatives;Unnatural Amino Acid Derivatives;Amines;Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Biology;Chemical Synthesis;Esters;Nitrogen Compounds;Organic Building Blocks;Peptide Chemistry
• Mol File: 60421-20-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 170-171℃
• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble50mg/mL, clear, colorless
• BRN: 5149947
• CAS DataBase Reference: H-Aib-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: H-Aib-OBzl(60421-20-7)
• EPA Substance Registry System: H-Aib-OBzl(60421-20-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 60421-20-7(Hazardous Substances Data)

Usage

General Description

H-Aib-OBzl is a chemical compound with the molecular formula C19H23NO3. It consists of an N-tert-butoxycarbonyl-protected amino acid derivative of α-aminoisobutyric acid (Aib) with a benzyl ester group. H-Aib-OBzl is commonly used in peptide synthesis as a building block for the formation of larger peptide and protein structures. It is known for its high stability and the ability to withstand harsh reaction conditions, making it a valuable tool in the field of medicinal chemistry and biochemistry. Additionally, H-Aib-OBzl is utilized in the chemical modification of peptides and proteins for various research and industrial applications.

Upstream product

• 62-57-7 2-Aminoisobutyric acid 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 55456-40-1 benzyl 2-aminoisobutyrate 
• 84758-57-6 tert-butoxycarbonylamino-2-methyl-propionic acid benzyl ester 

Downstream Products

• 79118-36-8 Boc-MeA-MeA-OBzl 
• 1029585-09-8 C₂₆H₃₉N₃O₆ 
• 1177451-85-2 C₁₈H₂₁ClNO₅P 
• 915087-33-1 enzalutamide 
• 1289942-66-0 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid 
• 1427195-82-1 benzyl 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]phenyl}butanoylamino)-2-methylpropanoate 
• 1126529-10-9 Boc-ACPC-ACPC-Aib-OBn 
• 661481-34-1 3-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyloxy)-4-[(4-{4-[1-benzyloxycarbonyl-1-(methyl)ethylcarbamoyl]but-1-ynyl}phenyl)methyl]-5-isopropyl-1H-pyrazole 
• 661481-25-0 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-[(4-{2-[1-benzyloxycarbonyl-1-(methyl)ethylcarbamoyl]ethoxy}-2-methylphenyl)methyl]-5-isopropyl-1H-pyrazole 
• 55456-40-1 benzyl 2-aminoisobutyrate 
• 92398-39-5 L-aspartyl-α-aminoisobutyric acid benzyl ester 
• 219561-11-2 2-Methyl-2-{3-[(R)-1-methyl-1-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-2-phenyl-ethyl]-oxaziridin-2-yl}-propionic acid benzyl ester 
• 840506-42-5 benzyl 2-((chloro(phenoxy)phosphoryl)amino)-2-methylpropanoate 
• 92398-57-7 N-(tert-butyloxycarbonyl)-β-tert-butyl-L-aspartyl-α-aminoisobutyric acid benzyl ester 

Relevant articles and documents

ANTIVIRAL PRODRUGS OF TENOFOVIR

Compounds of Formula I: and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

PHOSPHORAMIDATE PRODRUGS FOR TREATMENT OF VIRAL INFECTION

The invention concerns 2'-methyl ribonucleotide phosphoramidates which are neutral prodrugs which are converted in vivo to 2'- methyl ribonucleotide triphosphates. These compounds are useful in the treatment of viral infection. Of particular interest are prodrugs of a methylsulfonylhydrazinyl purine 2'-methyl nucleotide triphosphate: 2'methyl- N6-alkyl-N6- (N-methylsulfonamide) adenosine triphosphate and its 2-amino derivative.

FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF

The present invention provides fused heterocyclic derivatives represented by the general formula: wherein R1 represents H, halogen, OH, etc.; R2 represents H, halogen or an alkyl group; R3 and R4 represent H, OH, halogen, etc.; Q represents alkylene, etc.; ring A represents aryl or heteroaryl; and G represents or ???or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.