(E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one

Base Information

• Chemical Name: (E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one
• CAS No.: 1392485-19-6
• Molecular Formula: C₁₈H₁₅ClO₂
• Molecular Weight: 298.769
• Mol file: 1392485-19-6.mol

Synonyms:(E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one

Chemical Property of (E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one

There total 2 articles about (E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

phenylpropynoic acid ethyl ester (2216-94-6) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one (1392485-19-6)

Guidance literature:

With copper(II) choride dihydrate; oxygen; palladium dichloride; In acetonitrile; benzene; at 100 ℃; for 12h; under 760.051 Torr;

DOI:10.1002/anie.201109141

Reference yield:

phenylpropyolic acid (637-44-5) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (Z)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one (1392485-78-7) + (E)-3-(chloro(phenyl)methylene)-5-methyl-5-phenyldihydrofuran-2(3H)-one (1392485-19-6)

Guidance literature:

With copper dichloride; palladium dichloride; In acetonitrile; at 20 ℃; for 5h; Overall yield = 82 %; Overall yield = 122.2 mg; stereoselective reaction;

DOI:10.1021/jo501606c

upstream raw materials:

phenylpropynoic acid ethyl ester

isopropenylbenzene

phenylpropyolic acid