N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Base Information

Chemical Name:N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide
CAS No.:1384875-42-6
Molecular Formula:C₂₄H₃₁N₇O₂S
Molecular Weight:481.622
Hs Code.:

Synonyms:N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

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Chemical Property of N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

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Technology Process of N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

There total 6 articles about N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384876-12-3
tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

: 1384875-42-6
N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Guidance literature:: tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1384875-42-6
N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / water / 16 h / 100 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

2.2: 0.25 h

3.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: triphenylphosphine; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide / tetrahydrofuran / 16 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With ammonium formate; potassium carbonate; SULFAMIDE; caesium carbonate; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide; triphenylphosphine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;

Reference yield:

: 1261358-78-4
4-(4-benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 1384875-42-6
N-[[(2S)-1-benzylpyrrolidin-2-yl]methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

1.2: 0.25 h

2.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: triphenylphosphine; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With ammonium formate; SULFAMIDE; caesium carbonate; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide; triphenylphosphine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;