tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

Base Information

Chemical Name:tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate
CAS No.:1384876-12-3
Molecular Formula:C₃₄H₄₇N₇O₆S
Molecular Weight:681.856
Hs Code.:

tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

Synonyms:tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

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Chemical Property of tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

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Technology Process of tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

There total 5 articles about tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384876-11-2
tert-butyl 4-[8-(tert-butoxycarbonylsulfamoyl)-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

: 53912-80-4
(S)-N-benzylprolinol

: 1384876-12-3
tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

Guidance literature:: With (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1384876-12-3
tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water / 16 h / 100 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

2.2: 0.25 h

3.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: triphenylphosphine; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide / tetrahydrofuran / 16 h / 0 - 20 °C

With ammonium formate; potassium carbonate; SULFAMIDE; caesium carbonate; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;

Reference yield:

: 1261358-78-4
4-(4-benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 1384876-12-3
tert-butyl 4-[8-[[(2S)-1-benzylpyrrolidin-2-yl]methyl-tert-butoxycarbonyl-sulfamoyl]-5,8-diazaspiro[2.5]octan-5-yl]pyrrolo[2,3-d]pyrimidine-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

1.2: 0.25 h

2.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: triphenylphosphine; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide / tetrahydrofuran / 16 h / 0 - 20 °C

With ammonium formate; SULFAMIDE; caesium carbonate; (Z)-N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;