1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid

Base Information

Chemical Name:1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid
CAS No.:50264-71-6
Molecular Formula:C₁₆H₁₄N₂O₃
Molecular Weight:282.299
Hs Code.:
European Community (EC) Number:807-249-1

Synonyms:50264-71-6;1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid;1-(4-Methoxybenzyl)-1H-indazole-3-carboxylic acid;1-[(4-methoxyphenyl)methyl]indazole-3-carboxylic acid;SCHEMBL2432735;GPLVXAMBUCHFJE-UHFFFAOYSA-N;AKOS012407077;SS-4828;1-(4-methoxybenzyl)-3-indazolylcarboxylicacid;1-(4-methoxybenzyl)-3-indazolylcarboxylic acid;1-(4-Methoxybenzyl)-1H-indazole-3-carboxylicacid

Suppliers and Price of 1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:282.10044231
Heavy Atom Count:21
Complexity:369

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C(=O)O

Technology Process of 1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid

There total 4 articles about 1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 441717-61-9
methyl 1-(4-methoxybenzyl)-1H-indazole-3-carboxylate

: 50264-71-6
1-(4-methoxybenzyl)-3-indazolylcarboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1002/cmdc.201700446

Reference yield:

: 4498-67-3
1H-Indazole-3-carboxylic acid

: 50264-71-6
1-(4-methoxybenzyl)-3-indazolylcarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Reflux

2: N,N-dimethyl-formamide / 2 h / 60 °C

3: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

With thionyl chloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201700446

Reference yield:

: 43120-28-1
methyl 1H-indazole-3-carboxylate

: 50264-71-6
1-(4-methoxybenzyl)-3-indazolylcarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 2 h / 60 °C

2: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201700446