1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

Base Information

Chemical Name:1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid
CAS No.:1455087-12-3
Molecular Formula:C₂₂H₂₀N₂O₅
Molecular Weight:392.411
Hs Code.:

Synonyms:1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

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Chemical Property of 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

Chemical Property:

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Technology Process of 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

There total 7 articles about 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455091-26-5
1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid methyl ester

: 1455087-12-3
1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455087-12-3
1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: methanol / 8.33 h / 150 °C

4: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

With sodium methylate; potassium carbonate; sodium iodide; lithium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1455091-10-7
4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 1455087-12-3
1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 8.33 h / 150 °C

2: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

With lithium hydroxide; In tetrahydrofuran; methanol; water;