2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

Base Information

• Chemical Name: 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester
• CAS No.: 1455091-06-1
• Molecular Formula: C₂₅H₂₅NO₇S
• Molecular Weight: 483.542
• Mol file: 1455091-06-1.mol

Synonyms:2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

Chemical Property of 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

There total 9 articles about 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl tosylglycinate (2645-02-5) + 2-(bromomethyl)-4-phenoxybenzoic acid methyl ester → 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester (1455091-06-1)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester (1455091-04-9) + methyl tosylglycinate (2645-02-5) → 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester (1455091-06-1)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

5-bromophthalide (64169-34-2) → 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester (1455091-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate / 1-methyl-pyrrolidin-2-one / 64 h / 130 °C

2.1: Triphenylphosphine oxide; thionyl chloride; boric acid / Reflux

2.2: 1 h / Reflux

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

With thionyl chloride; 2,2,6,6-tetramethylheptane-3,5-dione; boric acid; potassium carbonate; caesium carbonate; Triphenylphosphine oxide; sodium iodide; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

upstream raw materials:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

methyl tosylglycinate

5-bromophthalide

phenol

Downstream raw materials:

[(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid

4-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}tetrahydropyran-4-carboxylic acid

4-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}tetrahydropyran-4-carboxylic acid methyl ester

1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid