Technology Process of (S)-methyl 2-acetamido-3-[2H]-3(4-nitrophenyl)propanoate
There total 4 articles about (S)-methyl 2-acetamido-3-[2H]-3(4-nitrophenyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen;
In
methanol;
for 1.5h;
under 5171.62 Torr;
DOI:10.1002/anie.201311061
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium acetate / acetic anhydride / 100 °C
2: methanol / 0.5 h / 20 °C
3: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
With
(+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; sodium acetate;
In
methanol; acetic anhydride;
DOI:10.1002/anie.201311061
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium deuteride / diethylene glycol dimethyl ether; tert-butyl alcohol / 0.5 h / -78 °C
2: sodium acetate / acetic anhydride / 100 °C
3: methanol / 0.5 h / 20 °C
4: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
With
lithium aluminium deuteride; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; sodium acetate;
In
methanol; diethylene glycol dimethyl ether; acetic anhydride; tert-butyl alcohol;
DOI:10.1002/anie.201311061