trans-2-Aminocyclo hexanol hydrochloride

Base Information

• Chemical Name: trans-2-Aminocyclo hexanol hydrochloride
• CAS No.: 13374-30-6
• Molecular Formula: C6H13NOHCl
• Molecular Weight: 151.636
• Hs Code.: 2922199090
• Mol file: 13374-30-6.mol

Synonyms:Trans (1S,2S)-2-amino-cyclohexanol hydrochloride;

Chemical Property of trans-2-Aminocyclo hexanol hydrochloride

Chemical Property:

• Vapor Pressure: 0.0773mmHg at 25°C
• Boiling Point: 201.1 °C at 760 mmHg
• Flash Point: 75.4 °C
• PSA: 46.25000
• LogP: 1.75090
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(1S,2S)-2-AminocyclohexanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-2-Aminocyclo hexanol hydrochloride

There total 17 articles about trans-2-Aminocyclo hexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trans-2-acetamidocyclohexyl acetate (202461-26-5) → (1S,2S)-2-hydroxycyclohexylamine hydrochloride (13374-30-6)

Guidance literature:

With hydrogenchloride; for 3h; Heating;

DOI:10.1016/S0040-4020(00)00884-X

Reference yield: 82.0%

N-(cis-2-hydroxycyclohexyl)benzamide (5450-83-9,23551-93-1,33092-84-1,64757-25-1,116429-77-7) → trans-2-hydroxycyclohexylamine hydrochloride (5456-63-3,6936-47-6,13374-30-6,13374-31-7,33092-83-0,38898-68-9,89584-01-0)

Guidance literature:

With hydrogenchloride; In methanol; water; for 24h; Heating;

Reference yield: 73.0%

1,2-cis-(1,3-dihydroisobenzofuran-1-ylideneamino)cyclohexanol (106729-83-3,123132-96-7) → trans-2-hydroxycyclohexylamine hydrochloride (5456-63-3,6936-47-6,13374-30-6,13374-31-7,33092-83-0,38898-68-9,89584-01-0)

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Heating;

upstream raw materials:

N-(cis-2-hydroxycyclohexyl)benzamide

cis-2-benzamidocyclohexyl benzoate

1,2-cis-(1,3-dihydroisobenzofuran-1-ylideneamino)cyclohexanol

(1S,2R)-2-[3H-Isobenzofuran-(1Z)-ylideneamino]-cyclohexanol

Downstream raw materials:

(1S,2S)-N-(2-hydroxycyclohexyl)acetamide

2,2-Difluoro-3-hydroxy-dodecanoic acid ((1S,2S)-2-hydroxy-cyclohexyl)-amide

(1S,2S)-N-(2-hydroxycyclohexyl)butyramide

(1S,2S)-2-tert-Butoxycarbonylamino-1-cyclohexanol

Refernces

• 1、 Schaus, Scott E.,Larrow, Jay F.,Jacobsen, Eric N.. "Practical Synthesis of Enantiopure Cyclic 1,2-Amino Alcohols via Catalytic Asymmetric Ring Opening of Meso Epoxides". . p. 4197 - 4199. Retrieved 2007/10/03.
• 2、 Sammes, Peter G.,Thetford, Dean. "SYNTHESIS OF (L)-DAUNOSAMINE AND RELATED AMINO SUGARS". . p. 111 - 124. Retrieved 2007/10/02.