[5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol

Base Information

• Chemical Name: [5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol
• CAS No.: 114199-35-8
• Molecular Formula: C₁₄H₁₃Cl₂NO₂S
• Molecular Weight: 330.235

Synonyms:[5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol

Chemical Property of [5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol

Chemical Property:

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Technology Process of [5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol

There total 2 articles about [5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-(4-Chloro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester (114199-29-0) → [5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol (114199-35-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; Heating;

DOI:10.1021/jm00402a030

Reference yield:

3-(4-Chloro-benzoyl)-thiazolidine-2-carboxylic acid (114199-24-5) → [5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol (114199-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Ac₂O / Heating

2: 87 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / Heating

With lithium aluminium tetrahydride; acetic anhydride; In diethyl ether; dichloromethane;

DOI:10.1021/jm00402a030

Reference yield: 90.0%

[5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol (114199-35-8) + Isopropyl isocyanate (1795-48-8) → 5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate) (114199-39-2)

Guidance literature:

With triethylamine; In dichloromethane; for 24h; Heating;

DOI:10.1021/jm00402a030

upstream raw materials:

5-(4-Chloro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

3-(4-Chloro-benzoyl)-thiazolidine-2-carboxylic acid

Downstream raw materials:

5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

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