5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

Base Information

Chemical Name:5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)
CAS No.:114199-39-2
Molecular Formula:C₂₂H₂₇Cl₂N₃O₄S
Molecular Weight:500.446
Hs Code.:

Synonyms:5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

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Chemical Property of 5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

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Technology Process of 5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

There total 3 articles about 5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 114199-35-8
[5-(3,4-Dichloro-phenyl)-7-hydroxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-yl]-methanol

: 1795-48-8
Isopropyl isocyanate

: 114199-39-2
5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

Guidance literature:: With triethylamine; In dichloromethane; for 24h; Heating;
DOI:10.1021/jm00402a030

Reference yield:

: 114199-24-5
3-(4-Chloro-benzoyl)-thiazolidine-2-carboxylic acid

: 114199-39-2
5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / Ac₂O / Heating

2: 87 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / Heating

3: 90 percent / Et₃N / CH₂Cl₂ / 24 h / Heating

With lithium aluminium tetrahydride; acetic anhydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jm00402a030

Reference yield:

: 114199-29-0
5-(4-Chloro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

: 114199-39-2
5-(3,4-dichlorophenyl)-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-methanol 6,7-bis(isopropylcarbamate)

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / Heating

2: 90 percent / Et₃N / CH₂Cl₂ / 24 h / Heating

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jm00402a030