[6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

Base Information

Chemical Name:[6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone
CAS No.:1361252-76-7
Molecular Formula:C₂₂H₁₇NO₃S
Molecular Weight:375.448
Hs Code.:

Synonyms:[6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

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Chemical Property of [6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

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Technology Process of [6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

There total 6 articles about [6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1361253-13-5
[6-(benzyloxy)-1,3-benzothiazol-2-yl][3-(tert-butyldimethylsilanyloxy)-4-methylphenyl]methanone

: 1361252-76-7
[6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm201711b

Reference yield:

: 13599-84-3
6-hydroxybenzothiazole

: 1361252-76-7
[6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with acetone-dry ice

2.2: 2 h / Cooling with acetone-dry ice

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 18.17 h / 0 - 60 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; acetone;
DOI:10.1021/jm201711b

Reference yield:

: 1361253-12-4
[6-(benzyloxy)-1,3-benzothiazol-2-yl][3-(tert-butyldimethylsilanyloxy)-4-methylphenyl]methanol

: 1361252-76-7
[6-(benzyloxy)-1,3-benzothiazol-2-yl](3-hydroxy-4-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 18.17 h / 0 - 60 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran;
DOI:10.1021/jm201711b