(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

Base Information

Chemical Name:(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol
CAS No.:1401163-61-8
Molecular Formula:C₂₀H₂₄F₄N₂O
Molecular Weight:384.417
Hs Code.:

Synonyms:(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

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Chemical Property of (3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

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Technology Process of (3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

There total 5 articles about (3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401163-63-0
(R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methylene)amino]-2,4-dimethylpentan-2-ol

: 1401163-61-8
(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

Guidance literature:: With hydrogen; Raney nickel; In methanol; at 20 ℃; for 48h; under 1551.49 Torr;

Reference yield:

: 106391-85-9
(R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate

: 1401163-61-8
(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

3.1: triethylamine / methanol / 1.5 h / 20 °C

3.2: 20 °C

4.1: hydrogen / Raney nickel / methanol / 48 h / 20 °C / 1551.49 Torr

With hydrogenchloride; hydrogen; triethylamine; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether;

Reference yield:

: (R)-methyl 2-amino-3-methylbutanoate hydrochloride

: 1401163-61-8
(3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-2,4-dimethylpentan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; methanol / 0 - 20 °C

2.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

4.1: triethylamine / methanol / 1.5 h / 20 °C

4.2: 20 °C

5.1: hydrogen / Raney nickel / methanol / 48 h / 20 °C / 1551.49 Torr

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; triethylamine; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether;