(S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol

Base Information

• Chemical Name: (S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol
• CAS No.: 1403755-28-1
• Molecular Formula: C₃₂H₄₁NO
• Molecular Weight: 455.684
• Mol file: 1403755-28-1.mol

Synonyms:(S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol

Chemical Property of (S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol

There total 1 articles about (S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-bromo-4-tert-butylbenzene (3972-65-4) + N-benzyl-(S)-proline methyl ester (113304-84-0,127986-89-4) → (S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol (1403755-28-1)

Guidance literature:

1-bromo-4-tert-butylbenzene; With magnesium; In tetrahydrofuran; at 90 ℃; for 1.5h;

N-benzyl-(S)-proline methyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 17.5h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; for 0.583333h;

DOI:10.1002/chem.201201316

Reference yield: 95.0%

(S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol (1403755-28-1) → (S)-α,α-Bis(4-(1,1-dimethylethyl)phenyl)-2-pyrrolidinemethanol (131180-55-7)

Guidance literature:

With sulfuric acid; palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 48h;

DOI:10.1002/chem.201201316

Reference yield:

(S)-(1-benzylpyrrolidin-2-yl)bis[4-(tert-butyl)phenyl]methanol (1403755-28-1) → C27H36FNO

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; palladium 10% on activated carbon; hydrogen / ethanol / 48 h / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 8 h / 0 °C

3: dmap / chloroform / 20 °C

With dmap; diethylamino-sulfur trifluoride; sulfuric acid; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; chloroform;

DOI:10.1002/chem.201201316

upstream raw materials:

1-bromo-4-tert-butylbenzene

N-benzyl-(S)-proline methyl ester

Downstream raw materials:

(S)-α,α-Bis(4-(1,1-dimethylethyl)phenyl)-2-pyrrolidinemethanol

(S,E)-2-(bis(4-(tert-butyl)phenyl)fluoromethyl)-1-((E)-3-phenylallylidene)pyrrolidinium perchlorate

(S)-2-(bis(4-(tert-butyl)phenyl)fluoromethyl)pyrrolidinium perchlorate

(S)-2-{bis[4-(tert-butyl)phenyl]fluoromethyl}pyrrolidine