4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
CAS No.:186300-92-5
Molecular Formula:C₂₀H₂₀FIN₄O₃
Molecular Weight:510.307
Hs Code.:

Synonyms:4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Suppliers and Price of 4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

There total 4 articles about 4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 371-40-4
4-fluoroaniline

: 186394-15-0
4-chloro-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

: 186300-92-5
4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: With sodium acetate; In ethanol; for 24h; Heating;
DOI:10.1021/jm0000259

Reference yield:

: 123148-78-7
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

: 186300-92-5
4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / acetonitrile / 16 h / Ambient temperature

2: 76 percent / NaOAc*3H₂O / ethanol / 72 h / Heating

With sodium acetate; sodium hydride; In ethanol; acetonitrile;
DOI:10.1080/07328319708006124

Reference yield:

: 158112-53-9
(3aR,6R,6aR)-2,2,6-trimethyltetrahydro-2H-furo(3,4-d)(1,3)dioxol-4-ol

: 186300-92-5
4-N-(4-fluorophenyl)amino-5-iodo-7-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: CCl₄ / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.75 h / -78 - -68 °C

2: NaH / acetonitrile / 16 h / Ambient temperature

3: 76 percent / NaOAc*3H₂O / ethanol / 72 h / Heating

With tetrachloromethane; sodium acetate; sodium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; acetonitrile;
DOI:10.1080/07328319708006124