3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid

Base Information

• Chemical Name: 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid
• CAS No.: 1447332-02-6
• Molecular Formula: C₂₇H₃₂N₄O₆
• Molecular Weight: 508.574
• Mol file: 1447332-02-6.mol

Synonyms:3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid

Chemical Property of 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid

There total 10 articles about 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid methyl ester (1447331-52-3) → 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid (1447332-02-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2013.05.019

Reference yield:

3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid (83747-30-2) → 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid (1447332-02-6)

Guidance literature:

Multi-step reaction with 5 steps

1: nitric acid / water; sulfuric acid / 6 h / -5 °C

2: sulfuric acid / 3 h / Reflux

3: hydrogen; palladium on activated charcoal / methanol / 7 h / 20 °C

4: triethylamine / acetonitrile / -5 - 20 °C

5: sodium hydroxide / water; methanol / 20 °C

With sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; triethylamine; sodium hydroxide; In methanol; sulfuric acid; water; acetonitrile;

DOI:10.1016/j.bmc.2013.05.019

Reference yield:

3-piperazine-4-yl-benzoic acid methyl ester (179003-08-8) → 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid (1447332-02-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 °C

2: sodium hydroxide / water / 6 h / 40 °C

3: triethylamine / acetonitrile / -5 - 20 °C

4: sodium hydroxide / water; methanol / 20 °C

With triethylamine; sodium hydroxide; In methanol; water; acetonitrile;

DOI:10.1016/j.bmc.2013.05.019

upstream raw materials:

3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid

3-phthalimidopropanoic acid

3-piperazine-4-yl-benzoic acid methyl ester

3-(6-nitro-1-oxo-1,3-dihydroisoindol-2-yl)propionic acid

Downstream raw materials:

3-[1-oxo-6-(3-piperazinium-1-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]propionic acid trifluoroacetate